UC Irvine Research Shows This is Your Brain Off Marijuana so Fat Can Burn

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Anyone who has seen Michael Blieden's seminal Super High Me knows that his Morgan Spurlock (comedian Doug Benson) lost weight while off pot for 30 days and gained back mucho poundage smoking the herb daily for the following month. Keep that in mind while checking out UC Irvine pharmacology professor Daniele Piomelli's latest research, which suggests that blocking a marijuana-like chemical in the brain leads to fattie, I mean, fat burning.

Piomelli, Andrea Frontini and Saverio Cinti of Marche Polytechnic University in Ancona, Italy, and their UCI and Yale colleagues engineered neurons in the forebrains of mice to limit production of an endocannabinoid compound called 2-AG, something that all mammal brains contain, in an area believed to control energy dissipation. The mice ate more (from a high-fat diet!) and moved less than normal mice without gaining weight.

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UCI.edu
Daniele Piomelli is UCI's Louise Turner Arnold Chair in the Neurosciences.
Give me a dozen! No, not the mice.

The researchers further found those mice did not develop high blood pressure or health problems such as diabetes, cardiovascular disease or others associated with obesity.

"We discovered that these mice were resistant to obesity because they burned fat calories much more efficiently than normal mice do," says Piomelli in a UC Irvine release. "We had known that endocannabinoids play a critical role in cell energy regulation, but this is the first time we found a target where this occurs."

On the possibility of this leading to a proven weight-loss drug, Piomelli says, "To produce the desired effects, we would need to create a drug that blocks 2-AG production in the brain, something we're not yet able to do. So don't cancel that gym membership just yet. But as you hit the treadmill, think about the added health benefits if you could train your brain to make fewer endocannabinoids."

The findings appear in the March issue of Cell Metabolism.

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13 comments
Joseph Manuel
Joseph Manuel

Unfortunately the research for cannabis alone in the USA is limited by the dictatorship of the majority. But, European studies of both cannabis and its human counterpart do show that the human body is wired for THC. It has also been found in this research that the "human cannabinoid" is responsible for dealing with stress and anxiety, which can cause some people to eat. In this research a weight loss drug was created based on blocking this chemical. Unfortunately, this chemical serves another purpose, one similar to that given to cannabis, cancer fighting properties. With out actually talking about the entire episode of CNBC's "Marijuana Inc.," the creators of the weight loss drug based on blocking the "human cannabinoid" put patients at a HIGHER RISK OF CANCER. It would appear the the USA is behind the ball again because of the dictatorship of the majority.

zongzeee4
zongzeee4

Looks like someone is having a good ole time for sure. WOw.Total-Privacy dot US

Henrye
Henrye

I'm not sure how this is actually connected to marijuana but from my own experience; During the years that i smoked pot regularly I was the thinnest I've been since early high school. Last year I took a job overseas in a country where it is much more difficult to get weed so I rarely smoked at all. During that time I gained about 20 - 25 pounds. When I had 3 months back in the states and smoked everyday I started to loose weight almost immediately despite almost zero exercise of any kind. Now back in Europe I'm gaining weight again, despite going to the gym 2-3 times a week. In short my experience is the opposite, weed helped me loose weight, being off weed made me gain weight.

John Malley
John Malley

I'm so sick of false headlines by untrained writers just filling space. Go get a job where you don't have to think 'cause this one isn't for you friend.

Daveholio
Daveholio

I almost didn't digg this due to the confusing (and inaccurate?) title, but the body of the article seems to be correct.

I think this quote "think about the added health benefits if you could train your brain to make fewer endocannabinoids" may be quite telling, especially since research has found that cannabis consumers have significantly lower obesity rates than the general population. Perhaps regular use of cannabis does indeed train your brain to make fewer endocannabiniods, or at least the ones involved in weight gain (2-AG).

Muzzy Lu
Muzzy Lu

Make your own medical marijuana treats. This book has great recipes for edible marijuana that are easy, small and cheap to make: MARIJUANA - Guide to Buying, Growing, Harvesting, and Making Medical Marijuana Oil and Delicious Candies to Treat Pain and Ailments by Mary Bendis, Second Edition. Learn to make marijuana oil, delicious Cannabis Chocolates, and tasty Dragon Teeth Mints. 

Staccs420
Staccs420

Wtf? Im confused here..what does this have to do with marijuana? "limit production of an endocannabinoid compoundcalled 2-AG, something that all mammal brains contain, in an area believed to control energydissipation."..."marijuana-like chemical".So your saying they are similar chemicals but endocannabinoid is not marijuana..why link them? And do you even read your headlines? Like wtf does that mean?

Christopher Neal
Christopher Neal

So what I think this is saying is if you smoke out before going to the gym, you will move less but lose more.

Bill T.
Bill T.

Yah, I was wondering about what other effects my play in. I suspect that these are just the tip of the iceberg but I don't really know.

Craigley
Craigley

I quit the cheeba and dropped 50lbs.  

Daveholio
Daveholio

 Cannabiniods and endocannabiniods are indistingushable to our bodies' cannabaniod receptors - they will happily utilize both.

stev0205
stev0205

While THC is not the only mind-altering chemical compound found in Cannabis, I could not find anything about the endocannabinoid 2-AG occurring in Cannabis.

I would have to guess this is a fairly misguided attempt at showing people that cannabinoids, which are found in Cannabis, are also naturally occurring in the human brain... Possibly hoping people would realize that it's a pretty harmless substance.

Bill T.
Bill T.

The author's, Henrye's and your testimonials are all just that, testimonials (anecdotal), hence at the best only suggestive, not to be taken as actual factual evidence.

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